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Antidote for Cyanide Poisoning

Amyl nitrite, sodium nitrite, and sodium thiosulfate are antidotes for cyanide toxicity.

The antidote is recommended by many in the fire service to be used specifically for chemical or industrial cyanide poisoning.

Amyl nitrite, sodium nitrite, and sodium thiosulfate are antidotes for cyanide toxicity; however, amyl nitrite and sodium nitrite should not be administered to patients/victims suffering from smoke inhalation. In these cases, only administer sodium thiosulfate. The described administration of nitrites is based on a patient having normal hemoglobin levels. Below normal hemoglobin levels require titration of nitrites. For mild to moderate physical findings such as nausea, vomiting, palpitations, confusion, anxiety, dizziness (vertigo), and/or abnormally fast or deep respiration (hyperventilation):

Child (less than 55 pounds): Observe the patient/victim and administer 0.75 mL per pound of a 25% solution (1.65 mL per kilogram of a 25% solution) of sodium thiosulfate intravenously over a period of 10 minutes.

Adult: Observe the patient/victim and administer 12.5 g of a 25% solution (50 mL of a 25% solution) of sodium thiosulfate intravenously over a period of 10 minutes.

Source: Centers for Disease Control and Prevention
  • Read the main story, "House of Horrors," to learn why toxic chemicals emitted by furnishings and building materials may be killing firefighters.

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